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Xylosyl Extension of <i>O</i>-Glucose Glycans on the Extracellular Domain of NOTCH1 and NOTCH2 Regulates Notch Cell Surface Trafficking

Biochemical and genetic studies have indicated that <i>O</i>-linked glycosylation such as <i>O</i>-glucose (Glc), fucose (Fuc), and <i>N</i>-acetylglucosamine (GlcNAc) is critical for Notch signaling; however, it is not fully understood how <i>O</i>-glycans regulate the Notch receptor function. Notc...

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Uloženo v:
Hlavní autoři: Yusuke Urata, Wataru Saiki, Yohei Tsukamoto, Hiroaki Sago, Hideharu Hibi, Tetsuya Okajima, Hideyuki Takeuchi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-05-01
Edice:Cells
Témata:
xylosyl-extension
<i>O</i>-glucosylation
Notch signaling
quality control
xylosyltransferases
On-line přístup:https://www.mdpi.com/2073-4409/9/5/1220
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