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24-Norursodeoxycholic acid ameliorates experimental alcohol-related liver disease and activates hepatic PPARγ

Background & Aims: Alcohol-related liver disease (ALD) is a global healthcare challenge with limited treatment options. 24-Norursodeoxycholic acid (NorUDCA) is a synthetic bile acid with anti-inflammatory properties in experimental and human cholestatic liver diseases. In the present study, we e...

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Principais autores: Christoph Grander, Moritz Meyer, Daniel Steinacher, Thierry Claudel, Bela Hausmann, Petra Pjevac, Felix Grabherr, Georg Oberhuber, Manuel Grander, Natascha Brigo, Almina Jukic, Julian Schwärzler, Günter Weiss, Timon E. Adolph, Michael Trauner, Herbert Tilg
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2023-11-01
Serier:JHEP Reports
Fag:
Alcoholic liver disease
norUDCA
Microbiota
M2 macrophages
Ppar-gamma
Online adgang:http://www.sciencedirect.com/science/article/pii/S2589555923002033
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