Identification of Kinases and Phosphatases That Regulate ATG4B Activity by siRNA and Small Molecule Screening in Cells

Autophagy protease ATG4B is a key regulator of the LC3/GABARAP conjugation system required for autophagosome formation, maturation and closure. Members of the ATG4 and the LC3/GABARAP family have been implicated in various diseases including cancer, and targeting the ATG4B protease has been suggeste...

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Detalhes bibliográficos

Principais autores:	Niccolo Pengo, Krisna Prak, Joana R. Costa, Christin Luft, Alexander Agrotis, Jamie Freeman, Christina A. Gewinner, A. W. Edith Chan, David L. Selwood, Janos Kriston-Vizi, Robin Ketteler
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-11-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	ATG4B siRNA small molecule kinase phosphatase cDNA
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fcell.2018.00148/full
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