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Profiling morphologic MRI features of motor neuron disease caused by TARDBP mutations

ObjectiveMutations in the TARDBP gene are a rare cause of genetic motor neuron disease (MND). Morphologic MRI characteristics of MND patients carrying this mutation have been poorly described. Our objective was to investigate distinctive clinical and MRI features of a relatively large sample of MND...

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Principais autores: Edoardo Gioele Spinelli, Alma Ghirelli, Nilo Riva, Elisa Canu, Veronica Castelnovo, Teuta Domi, Laura Pozzi, Paola Carrera, Vincenzo Silani, Adriano Chiò, Massimo Filippi, Federica Agosta
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-07-01
Colecção:Frontiers in Neurology
Assuntos:
motor neuron disease (MND)
amyotrophic lateral sclerosis (ALS)
transactive response (TAR) DNA binding protein 43 (TARDBP)
magnetic resonance imaging (MRI)
voxel-based morphometry (VBM)
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fneur.2022.931006/full
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