Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA accessibility and activity of IRF4 in response to...
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| Główni autorzy: | , , , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Nature Portfolio
2020-01-01
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| Seria: | Nature Communications |
| Dostęp online: | https://doi.org/10.1038/s41467-019-14112-2 |
| Etykiety: |
Nie ma etykietki, Dołącz pierwszą etykiete!
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