Diet-metabolism-transcription axis modulates the sensitivity to CDK4/6 inhibitors through RB1 in prostate cancer

Summary: A high-fat diet (HFD) promotes tumor progression and therapeutic resistance, but its mechanistic role in prostate cancer (PCa) remains unclear. In this study, we show that an HFD not only accelerates PCa progression but also significantly reduces sensitivity to CDK4/6 inhibitors. Mechanisti...

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Autors principals:	Xurui Li, Zhenghui Sun, Ruijiang Zeng, Ruiling Liu, Pingxia Lin, Zhuo Xing, Xin Jin, Tiejun Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2025-11-01
Col·lecció:	Cell Reports
Matèries:	CP: cancer CP: metabolism
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124725013014
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