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255 A Bacterial Serine Protease Inhibitor, Ecotin Inhibits Neutrophil Elastase in Cystic Fibrosis Airway Samples

OBJECTIVES/GOALS: Ecotin is a potent periplasmic serin protease inhibitor that was first described in Escherichia coli (E. coli). Ecotin is known to inhibit a broad range of serine proteases including NE. Therefore, we hypothesized that ecotin can inhibit the NE activity present in CF clinical sputu...

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Autors principals: Kayla Fantone, Clay Crippen, Harald Nothaft, Arlene Stecenko, Christine Szymanski, Balazs Rada
Format: Artigo
Idioma:Inglês
Publicat: Cambridge University Press 2022-04-01
Col·lecció:Journal of Clinical and Translational Science
Accés en línia:https://www.cambridge.org/core/product/identifier/S2059866122001388/type/journal_article
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