Pharmacogenetic-based efavirenz dose modification: suggestions for an African population and the different CYP2B6 genotypes.

Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this study was to assess the effect of genetic factors on EFV pharmacokinetics, treatment outcomes and genotype based EFV dose...

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Egile Nagusiak:	Jackson K Mukonzo, Joel S Owen, Jasper Ogwal-Okeng, Ronald B Kuteesa, Sarah Nanzigu, Nelson Sewankambo, Lehana Thabane, Lars L Gustafsson, Colin Ross, Eleni Aklillu
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Public Library of Science (PLoS) 2014-01-01
Saila:	PLoS ONE
Sarrera elektronikoa:	http://europepmc.org/articles/PMC3909010?pdf=render
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