Defining bottlenecks and opportunities for Lassa virus neutralization by structural profiling of vaccine-induced polyclonal antibody responses

Summary: Lassa fever continues to be a major public health burden in West Africa, yet effective therapies or vaccines are lacking. The isolation of protective neutralizing antibodies against the Lassa virus glycoprotein complex (GPC) justifies the development of vaccines that can elicit strong neutr...

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Autors principals:	Philip J.M. Brouwer, Hailee R. Perrett, Tim Beaumont, Haye Nijhuis, Sabine Kruijer, Judith A. Burger, Ilja Bontjer, Wen-Hsin Lee, James A. Ferguson, Martin Schauflinger, Helena Müller-Kräuter, Rogier W. Sanders, Thomas Strecker, Marit J. van Gils, Andrew B. Ward
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	Cell Reports
Matèries:	CP: Molecular biology CP: Immunology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124724010593
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