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5-Methyltetrahydrofolate Attenuates Oxidative Stress and Improves Kidney Function in Acute Kidney Injury through Activation of Nrf2 and Antioxidant Defense

Oxidative stress is a major mediator of adverse outcomes in acute kidney injury (AKI). Deficiency of micronutrients, such as folate, is common in AKI. Our previous study reported that AKI impaired kidney reabsorption of folate and decreased plasma folate level in rats. The present study investigated...

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Principais autores: Charith U. B. Wijerathne, Kathy K. W. Au-Yeung, Yaw L. Siow, Karmin O
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-05-01
coleção:Antioxidants
Assuntos:
acute kidney injury (AKI)
oxidative stress
glutathione
ischemia-reperfusion
folic acid
Acesso em linha:https://www.mdpi.com/2076-3921/11/6/1046
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