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Direct endothelial ENaC activation mitigates vasculopathy induced by SARS-CoV2 spike protein

IntroductionAlthough both COVID-19 and non-COVID-19 ARDS can be accompanied by significantly increased levels of circulating cytokines, the former significantly differs from the latter by its higher vasculopathy, characterized by increased oxidative stress and coagulopathy in lung capillaries. This...

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Автори: Maritza J. Romero, Qian Yue, Bhupesh Singla, Jürg Hamacher, Supriya Sridhar, Auriel S. Moseley, Chang Song, Mobarak A. Mraheil, Bernhard Fischer, Markus Zeitlinger, Trinad Chakraborty, David Fulton, Lin Gan, Brian H. Annex, Gabor Csanyi, Douglas C. Eaton, Rudolf Lucas
Формат: Artigo
Мова:Inglês
Опубліковано: Frontiers Media S.A. 2023-08-01
Серія:Frontiers in Immunology
Предмети:
Epithelial sodium channel (ENaC)
SARS-CoV2 spike protein
receptor binding domain (RBD)
human ACE-2
endothelial dysfunction
NADPH oxidase 2 (NOX2)
Онлайн доступ:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1241448/full
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