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PF-03882845, a non-steroidal mineralocorticoid receptor antagonist, prevents renal injury with reduced risk of hyperkalemia in an animal model of nephropathy

The mineralocorticoid receptor (MR) antagonists PF 03882845 and eplerenone were evaluated for renal protection against aldosterone mediated renal disease in uninephrectomized Sprague Dawley (SD) rats maintained on a high salt diet and receiving aldosterone by osmotic mini pump for 27 days. Serum K+...

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Principais autores: Stephen eOrena, Tristan eMaurer, Rena eEudy, Li eShe, Darla eDash, Paula eLoria, Mary Ellen eBanker, Vincent eBernardo, Meera eTugnait, Carlin eOkerberg, Jessie eQian, Carine M Boustany-Kari
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2013-10-01
Serier:Frontiers in Pharmacology
Fag:
Albuminuria
Aldosterone
Hyperkalemia
Chronic Kidney Disease
mineralocorticoid receptor
diabetic nephropathy
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00115/full
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