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Targeting the CD47-HCK-LGALS9 axis disrupts proliferation-immunosuppression coupling in early-stage endometrial cancer

Abstract Backgrounds Significant heterogeneity was observed in the epithelial-derived endometrial cancer (EC), which contributes to different prognostic outcomes. While the mechanisms involved in this heterogeneity in the tumor microenvironment (TME) of early-stage EC remain poorly defined. Methods...

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Principais autores: Jingxuan Ye, Yitong Yan, Xiaoqi Sun, Qibin Wu, Yashi Shi, Maotong Zhang, Xite Lin, Yuan Ren, Xiaodan Mao, Mingyan Lin, Pengming Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Molecular Cancer
Fag:
Endometrial cancer
CD47
ERRγ
LGALS9
HCK
Immunosuppressive microenvironment
Online adgang:https://doi.org/10.1186/s12943-025-02534-0
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