Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder caused by pathogenic variants in TSC1 and TSC2 genes. TSC patients present with seizures and brain abnormalities such as tubers and subependymal giant cells astrocytoma (SEGA). Despite common molecular and clinical features, the seve...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, James D. Mills, Alessia Romagnolo, Nicole N. Van Der Wel, Eleonora Aronica, Peter A. M. de Witte
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2022-09-01
Rangatū:	Frontiers in Cell and Developmental Biology
Ngā marau:	mTOR tuberous sclerosis complex (TSC) zebrafish epilepsy neurodevelopment RNA-sequencing
Urunga tuihono:	https://www.frontiersin.org/articles/10.3389/fcell.2022.952832/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!