An active allosteric mechanism in ASAP1-mediated Arf1 GTP hydrolysis redefines PH domain function

Abstract GTPase-activating proteins are important regulators of small GTPases; among these, ASAP1 stimulates GTP hydrolysis on Arf1 and is implicated in cancer progression. ASAP1 contains a Pleckstrin Homology (PH) domain essential for maximum Arf·GTP hydrolysis. The prevailing view of PH domains is...

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Bibliografiske detaljer

Principais autores:	Olivier Soubias, Samuel L. Foley, Xiaoying Jian, Rebekah A. Jackson, Yue Zhang, Eric M. Rosenberg, Benjamin J. Hu, Jess Li, Frank Heinrich, Margaret E. Johnson, Alexander J. Sodt, Paul A. Randazzo, R. Andrew Byrd
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2025-09-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-025-63764-w
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