Mass spectrometry-based de novo sequencing reveals non-canonical neoantigens with antitumor efficacy in hepatocellular carcinoma

Background & Aims: Tumor neoantigens, especially cryptic antigens from non-canonical translation, are vital for cancer immunotherapy. Mass spectrometry (MS)-based de novo sequencing identifies candidates, but unverified immunogenicity and antitumor efficacy limit clinical applicability. This stu...

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Detalhes bibliográficos

Principais autores:	Xiaohua Xing, Mingxin Liu, Jiahe Ouyang, Yaxin Tang, Baozhen Shan, Ruijing Tang, En Hu, Ming Li, Xiaolong Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-04-01
coleção:	JHEP Reports
Assuntos:	immunopeptidomics cryptic translation targeted mass spectrometry peptide vaccine T cell immunogenicity
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589555926000467
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