Mutagenesis of GPR139 reveals ways to create gain or loss of function receptors

Abstract GPR139 is a Gq‐coupled receptor activated by the essential amino acids L‐tryptophan (L‐Trp) and L‐phenylalanine (L‐Phe). We carried out mutagenesis studies of the human GPR139 receptor to identify the critical structural motifs required for GPR139 activation. We applied site‐directed and hi...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Lien Wang, Grace Lee, Amy Shih, Chester Kuei, Diane Nepomuceno, Michelle Wennerholm, Frances Fan, Jiejun Wu, Pascal Bonaventure, Timothy W. Lovenberg, Changlu Liu
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Wiley 2019-02-01
Цуврал:	Pharmacology Research & Perspectives
Нөхцлүүд:	calcium mobilization assay gain of function GPR139 homology model random mutagenesis reduction of function
Онлайн хандалт:	https://doi.org/10.1002/prp2.466
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!