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Hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect neurons from cardiac arrest–induced pyroptosis

Cardiac arrest can lead to severe neurological impairment as a result of inflammation, mitochondrial dysfunction, and post-cardiopulmonary resuscitation neurological damage. Hypoxic preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and red...

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Main Authors: Xiahong Tang, Nan Zheng, Qingming Lin, Yan You, Zheng Gong, Yangping Zhuang, Jiali Wu, Yu Wang, Hanlin Huang, Jun Ke, Feng Chen
Format: Artigo
Language:Inglês
Published: Wolters Kluwer Medknow Publications 2025-04-01
Series:Neural Regeneration Research
Subjects:
bone marrow–derived mesenchymal stem cells
cardiac arrest
cardiac resuscitation
hypoxic preconditioning
liver isoform of phosphofructokinase
mitochondria
neuroinflammation
oxidative stress
pyroptosis
reactive oxygen species
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01922
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