Mitomycin C-induced DNA double-strand breaks are enhanced by catalytical inactivation of DNA polymerase κ in mice

Abstract Background DNA polymerase κ (Polk), a member of Y-family DNA polymerases, plays an important role in translesion DNA synthesis (TLS), allowing DNA replication forks to bypass DNA damage or DNA adducts to continue daughter strand synthesis. Polk is also believed to contribute to the replicat...

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Principais autores:	Naoko A. Wada, Akira Takeiri, Shigeki Motoyama, Kaori Matsuzaki, Kenji Tanaka, Saori Matsuo, Etsuko Fujii-Takeiri, Hiromi Tateishi, Kaoru Matsumoto, Naoko Niimi, Akira Sassa, Petr Grúz, Kenichi Masumura, Masayuki Mishima, Kou-Ichi Jishage, Kei-Ichi Sugiyama, Takehiko Nohmi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	Genes and Environment
Assuntos:	Translesion DNA synthesis DNA polymerase κ Mitomycin C DNA double-strand breaks gpt delta mice
Acesso em linha:	https://doi.org/10.1186/s41021-025-00343-x
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