Characterization of essential domains in HSD17B13 for cellular localization and enzymatic activity

Human genetic studies recently identified an association of SNPs in the 17-β hydroxysteroid dehydrogenase 13 (HSD17B13) gene with alcoholic and nonalcoholic fatty liver disease development. Mutant HSD17B13 variants devoid of enzymatic function have been demonstrated to be protective from cirrhosis a...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Yanling Ma, Suman Karki, Philip M. Brown, Dennis D. Lin, Maren C. Podszun, Wenchang Zhou, Olga V. Belyaeva, Natalia Y. Kedishvili, Yaron Rotman
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Elsevier 2020-11-01
סדרה:	Journal of Lipid Research
נושאים:	nonalcoholic fatty liver disease alcoholic liver disease retinoids lipid droplets enzyme regulation protein structure
גישה מקוונת:	http://www.sciencedirect.com/science/article/pii/S0022227520437289
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