Determining site occupancy of acetaminophen covalent binding to target proteins in vitro

Abstract Acetaminophen (APAP)‐related toxicity is caused by the formation of N‐acetyl p‐benzoquinone imine (NAPQI), a reactive metabolite able to covalently bind to protein thiols. A targeted liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method, using multiple reaction monitoring (MRM),...

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Auteurs principaux:	Timon Geib, Cristina Lento, Vanessa Marensi, Madhuranayaki Thulasingam, Jesper Z. Haeggström, Magnus Olsson, Derek J. Wilson, Elaine M. Leslie, Lekha Sleno
Format:	Artigo
Langue:	Inglês
Publié:	Wiley-VCH 2021-06-01
Collection:	Analytical Science Advances
Sujets:	acetaminophen glutathione S‐transferase multiple reaction monitoring N‐acetyl p‐benzoquinone imine protein covalent binding protein modifications
Accès en ligne:	https://doi.org/10.1002/ansa.202000182
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