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New somatic BRAF splicing mutation in Langerhans cell histiocytosis

Abstract Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF V600 and MAP2K1 mutations by whole exome sequencing. We identified a new somatic BRAF splicing...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Sébastien Héritier, Zofia Hélias-Rodzewicz, Rikhia Chakraborty, Amel G. Sengal, Christine Bellanné-Chantelot, Caroline Thomas, Anne Moreau, Sylvie Fraitag, Carl E. Allen, Jean Donadieu, Jean-François Emile
Hōputu: Artigo
Reo:Inglês
I whakaputaina: BMC 2017-07-01
Rangatū:Molecular Cancer
Ngā marau:
Langerhans cell histiocytosis
BRAF
Splicing mutation
Targeted therapy
Urunga tuihono:http://link.springer.com/article/10.1186/s12943-017-0690-z
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