The neoepitope landscape of breast cancer: implications for immunotherapy

Abstract Background Cancer immunotherapy with immune checkpoint blockade (CKB) is now standard of care for multiple cancers. The clinical response to CKB is associated with T cell immunity targeting cancer-induced mutations that generate novel HLA-binding epitopes (neoepitopes). Methods Here, we dev...

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Autores principales:	Pooja Narang, Meixuan Chen, Amit A. Sharma, Karen S. Anderson, Melissa A. Wilson
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2019-03-01
Colección:	BMC Cancer
Materias:	Breast cancer Neoepitope prediction Mutation burden Immunotherapy TNBC Epitopes
Acceso en línea:	http://link.springer.com/article/10.1186/s12885-019-5402-1
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