Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity.

Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury. In fasted wildtype (WT) mice, APAP caused significant cellular necrosis, edema, and inflammation...

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Hlavní autoři:	Karen A Cavassani, Ana Paula Moreira, David Habiel, Toshihiro Ito, Ana Lucia Coelho, Ron M Allen, Bin Hu, Janna Raphelson, William F Carson, Matthew A Schaller, Nicholas W Lukacs, M Bishr Omary, Cory M Hogaboam, Steven L Kunkel
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2013-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3676358?pdf=render
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