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Aspirin alters molecular crosstalk between prostaglandin, apoptosis, and invasion pathways in colorectal cancer

Abstract Background Colorectal cancer (CRC) remains a significant cause of global cancer mortality. While aspirin demonstrates therapeutic benefits, the molecular determinants underlying patient response are poorly understood, hindering personalised treatment strategies. This study aimed to identify...

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Principais autores: Hanieh-Sadat Mostafavi-Fini, Arash Moradi, Erfan Gowdini, Ramtin Mohammadi, Tina Abdollahi, Faranak Jamshidian, Shahla Mohammad Ganji
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:BMC Cancer
Fag:
Colorectal cancer
Aspirin
Molecular subtypes
Prostaglandin pathway
PTGS2 (COX-2)
Caspase-8
Online adgang:https://doi.org/10.1186/s12885-026-15872-z
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