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Cre recombinase affects calcium dynamics already in young mice

BackgroundThe Cre/LoxP system is widely used in cardiovascular research to generate mouse models with tissue-specific inactivation of target genes. Studies have reported that expression of Cre recombinase under the αMHC promoter leads to age-dependent cardiotoxicity with ventricular hypertrophy, fib...

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Principais autores: János Levin Liffers, Jan Peter Reinhardt, Matthias Dodo Seidl, Uwe Kirchhefer, Frank Ulrich Müller, Jan Sebastian Schulte
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2025-03-01
Colecção:Frontiers in Pharmacology
Assuntos:
transgenic mice
cre recombinase
LoxP sites
Myh6-cre
cardiotoxicity
Ca2+ dynamics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2025.1558573/full
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