Modern xenotransplantation: rewiring glycan-mediated immunogenicity via genome-glycome convergence

Summary: Xenotransplantation addresses global organ shortages but faces species-specific glycan antigen barriers. Dominant xenoantigens (α-Gal, Neu5Gc, Sda) trigger hyperacute rejection via antibody-mediated immune cascades, complement activation, and thromboinflammation. Advances in precision genom...

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Autori principali:	Mingshuo Wang, Qing Wang, Yakun Liu, Jiatong Xu, Yuxin Su, Hui Bai, Yunfang Wang, Jiahong Dong
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2026-01-01
Serie:	EBioMedicine
Soggetti:	Xenotransplantation Immune rejection Glycan antigens Gene editing Glycomics Glycoproteomics
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2352396425005596
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