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Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma

Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significantly improved clinical outcome, most patients relapse and develop drug resistance. MM is characterized by genom...

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Autori principali: Angélique Bruyer, Laure Dutrieux, Hugues de Boussac, Thibaut Martin, Djamila Chemlal, Nicolas Robert, Guilhem Requirand, Guillaume Cartron, Laure Vincent, Charles Herbaux, Malik Lutzmann, Caroline Bret, Philippe Pasero, Jérôme Moreaux, Sara Ovejero
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-12-01
Serie:Frontiers in Oncology
Soggetti:
multiple myeloma
Chk1
Wee1
therapeutic targets
replicative stress
Accesso online:https://www.frontiersin.org/articles/10.3389/fonc.2023.1271847/full
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