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The phosphatases TCPTP, PTPN22, and SHP1 play unique roles in T cell phosphotyrosine maintenance and feedback regulation of the TCR

Abstract The protein tyrosine phosphatases (PTPs) TCPTP, PTPN22, and SHP1 are critical regulators of the activating phosphotyrosine (pY) site on the initiating T cell kinase, LckY394. Still, the broader implications of these phosphatases in T cell receptor (TCR) signalling and T cell biology remain...

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Автори: Aurora Callahan, Aisharja Mojumdar, Mengzhou Hu, Amber Wang, Alijah A. Griffith, Nicholas Huang, Xien Yu Chua, Nick Mroz, Ryan Z. Puterbaugh, Shanelle P. Reilly, Arthur Salomon
Формат: Artigo
Мова:Inglês
Опубліковано: Nature Portfolio 2025-07-01
Серія:Scientific Reports
Предмети:
Protein tyrosine phosphatases
Mass spectrometry
T cell signalling
Negative feedback
Positive feedback
Tyrosine phosphorylation
Онлайн доступ:https://doi.org/10.1038/s41598-025-12951-2
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