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QT interval prolongation in patients receiving bedaquiline-based regimens for drug-resistant tuberculosis in Sub-Saharan Africa: A systematic review and meta-analysis

Background: Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB treatment, is linked to QT interval prolongation, a risk factor for life-threatening...

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Principais autores: Morrish Obol Okello, Ivaan Pitua, James Nelson Okema, Doris Ekwem, Felix Bongomin, Ronald Olum
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-05-01
coleção:Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Assuntos:
Bedaquiline
QT prolongation
Drug-resistant tuberculosis
Sub-Saharan Africa
Meta-analysis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2405579426000148
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