Programmable protein stabilization with language model-derived peptide guides

Abstract Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. While small molecule-based targeted protein degradation (TPD) and targeted protein stabilization (TPS) platforms can address this...

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Detalhes bibliográficos

Principais autores:	Lauren Hong, Tianzheng Ye, Tian Z. Wang, Divya Srijay, Howard Liu, Lin Zhao, Rio Watson, Sophia Vincoff, Tianlai Chen, Kseniia Kholina, Shrey Goel, Matthew P. DeLisa, Pranam Chatterjee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-04-01
Colecção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-58872-6
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