Studying early structural changes in SOS1 mediated KRAS activation mechanism
KRAS activation is known to be modulated by a guanine nucleotide exchange factor (GEF), namely, Son of Sevenless1 (SOS1). SOS1 facilitates the exchange of GDP to GTP thereby leading to activation of KRAS. The binding of GDP/GTP to KRAS at the REM/allosteric site of SOS1 regulates the activation of K...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2024-01-01
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| Serie: | Current Research in Structural Biology |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2665928X23000211 |
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