Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype

Abstract Background The ε4 isoform of apolipoprotein E (ApoE) is the most significant genetic risk factor for Alzheimer’s disease. Glial cells are the main source of ApoE in the brain, and in microglia, the ε4 isoform of ApoE has been shown to impair mitochondrial metabolism and the uptake of lipids...

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Detalhes bibliográficos

Principais autores:	Marianna Hellén, Isabelle Weert, Stephan A. Müller, Noora Räsänen, Pinja Kettunen, Šárka Lehtonen, Michael Peitz, Klaus Fließbach, Mari Takalo, Marja Koskuvi, Stefan F. Lichtenthaler, Ville Leinonen, Alfredo Ramirez, Olli Kärkkäinen, Mikko Hiltunen, Jari Koistinaho, Taisia Rõlova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-06-01
coleção:	Journal of Neuroinflammation
Assuntos:	Microglia Alzheimer’s disease Apolipoprotein E iPSC Lysosomal dysfunction
Acesso em linha:	https://doi.org/10.1186/s12974-025-03470-y
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