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Plasma-Derived Extracellular Vesicle-Propagated microRNA From Aortic Stenosis Patients Render Pro-Calcifying Effects on Valve Interstitial Cells

Summary: Extracellular vesicles (EVs) and microRNAs (miRs) have been found to be differently expressed in patients with aortic valve stenosis (AS). Here, we profiled the expression of miRs associated with circulating EVs from severe AS patients and found several altered miRs compared with healthy co...

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Principais autores: Avinash B. Khandagale, PhD, Padraic Corcoran, PhD, Yuzhen Dan, PhD, Anders Isaksson, PhD, Stefan James, MD, PhD, Agneta Siegbahn, MD, PhD, Christina Christersson, MD, PhD
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-09-01
Serier:JACC: Basic to Translational Science
Fag:
aortic valve stenosis
calcified valve
extracellular vesicles
microRNA
transcatheter aortic valve replacement
valve interstitial cells
Online adgang:http://www.sciencedirect.com/science/article/pii/S2452302X25002797
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