TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

Abstract Entry into and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resid...

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Bibliografski detalji

Glavni autori:	Jennifer Kahlhofer, Nikolas Marchet, Kristian Zubak, Brigitta Seifert, Madlen Hotze, Anna-Sophia Egger-Hörschinger, Lucija Kucej, Claudia Manzl, Yannick Weyer, Sabine Weys, Martin Offterdinger, Sebastian Herzog, Veronika Reiterer, Chiara Volani, Marcel Kwiatkowski, Saskia B Wortmann, Siamak Nemati, Johannes A Mayr, Johannes Zschocke, Bernhard Radlinger, Kathrin Thedieck, Leopold Kremser, Bettina Sarg, Lukas A Huber, Hesso Farhan, Mariana E G de Araujo, Susanne Kaser, Sabine Scholl-Bürgi, Daniela Karall, David Teis
Format:	Artigo
Jezik:	Inglês
Izdano:	Springer Nature 2025-10-01
Serija:	The EMBO Journal
Teme:	Amino Acids Uptake Quiescence TXNIP SLC7A5/LAT1 Endocytosis
Online pristup:	https://doi.org/10.1038/s44318-025-00608-9
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