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In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation

Abstract Background Harnessing hepatocytes for basic research and regenerative medicine demands a complete understanding of the genetic determinants underlying hepatocyte differentiation and maturation. Single-cell CRISPR screens in organoids could link genetic perturbations with parallel transcript...

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Bibliografische gegevens
Hoofdauteurs: Junbo Liang, Jinsong Wei, Jun Cao, Jun Qian, Ran Gao, Xiaoyu Li, Dingding Wang, Yani Gu, Lei Dong, Jia Yu, Bing Zhao, Xiaoyue Wang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMC 2023-10-01
Reeks:Genome Biology
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Online toegang:https://doi.org/10.1186/s13059-023-03084-8
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