Silencing rapsyn in vivo decreases acetylcholine receptors and augments sodium channels and secondary postsynaptic membrane folding

The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular junction (NMJ) during development. Here we studied the role of rapsyn in the maintenance of the adult NMJ by...

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Principais autores:	Pilar Martínez-Martínez, Marko Phernambucq, Laura Steinbusch, Laurent Schaeffer, Sonia Berrih-Aknin, Hans Duimel, Peter Frederik, Peter Molenaar, Marc H. De Baets, Mario Losen
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2009-07-01
叢編:	Neurobiology of Disease
主題:	Rapsyn Voltage gated sodium channel Myasthenia gravis Neuromuscular junction Congenital myasthenic syndromes
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S096999610900059X
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