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Development of a novel ultrashort antimicrobial peptide-levofloxacin conjugate with enhanced synergistic activity against multidrug and levofloxacin-resistant bacterial isolates

Background and purpose: Antimicrobial resistance poses a significant global health threat. A previously developed penta-amino acid ultrashort antimicrobial peptide (UP5), with alternating arginine and biphenylalanine units, showed strong antimicrobial activity, particularly in combination with levof...

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Principais autores: Ammar Almaaytah, Aseel Alrashdan, Salsabeel H Sabi
Format: Artigo
Sprog:Inglês
Udgivet: Wolters Kluwer Medknow Publications 2025-11-01
Serier:Research in Pharmaceutical Sciences
Fag:
antimicrobial peptide
antimicrobial resistance
conjugation
drug design
levofloxacin
synergism
Online adgang:https://journals.lww.com/10.4103/RPS.RPS_178_24
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