DSS-induced colitis activates the kynurenine pathway in serum and brain by affecting IDO-1 and gut microbiota

Accumulative studies suggest that inflammatory bowel disease (IBD) may cause multiple central nervous system (CNS) pathologies. Studies have found that indoleamine-2,3-dioxygenase (IDO, rate-limiting enzyme of the kynurenine (Kyn) pathway) deficient mice were protected from endotoxin induced cogniti...

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Prif Awduron:	Li-Ping Zhao, Jian Wu, Wei Quan, Yu Zhou, Hui Hong, Gu-Yu Niu, Ting Li, Shu-Bing Huang, Chen-Meng Qiao, Wei-Jiang Zhao, Chun Cui, Yan-Qin Shen
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2023-01-01
Cyfres:	Frontiers in Immunology
Pynciau:	DSS-induced colitis tryptophan metabolism kynurenine pathway (KP) indoleamine-2,3-dioxygenase (IDO) gut microbiota
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1089200/full
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!