Integrating gene expression and splicing dynamics across dose-response oxidative modulators

Toxicological risk assessment increasingly utilizes transcriptomics to derive point of departure (POD) and modes of action (MOA) for chemicals. One essential biological process that allows a single gene to generate several different RNA isoforms is called alternative splicing. To comprehensively ass...

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Hlavní autoři:	A. Rasim Barutcu, Michael B. Black, Raymond Samuel, Scott Slattery, Patrick D. McMullen, Andy Nong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2024-05-01
Edice:	Frontiers in Genetics
Témata:	new approach methodologies transcriptomics mode of action benchmark dose alternative splicing
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fgene.2024.1389095/full
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