OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation

The re-wiring of the metabolic machinery is a common feature in cancer. Here, the authors show, using paired normal and prostate cancer samples that the cancer samples exhibit a shift to succinate respiration, which is associated with elevated levels of mitochondrial DNA mutations.

Bibliografiske detaljer

Principais autores:	Bernd Schöpf, Hansi Weissensteiner, Georg Schäfer, Federica Fazzini, Pornpimol Charoentong, Andreas Naschberger, Bernhard Rupp, Liane Fendt, Valesca Bukur, Irina Giese, Patrick Sorn, Ana Carolina Sant’Anna-Silva, Javier Iglesias-Gonzalez, Ugur Sahin, Florian Kronenberg, Erich Gnaiger, Helmut Klocker
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2020-03-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-020-15237-5
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!