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Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease

Abstract Background Thiopurines continue to play an important role in the treatment of inflammatory bowel disease (IBD). It is well known that thiopurines can cause several adverse reactions. Especially, hematopoietic toxicity may lead to severe agranulocytosis. In a previous prospective study, we i...

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Principais autores: Shizuka Suzuki, Kan Uchiyama, Yutaro Motoi, Yuuki Yoshii, Yukari Inoue, Takahiro Kubota, Shunichi Odahara, Yuichiro Ohtaki, Shinichiro Takami, Zensho Ito, Nobuhiro Sato, Toshifumi Ohkusa, Shigeo Koido, Masayuki Saruta
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2023-07-01
Serier:BMC Gastroenterology
Fag:
NUDT15
ITPA
Azathioprine
IBD
Online adgang:https://doi.org/10.1186/s12876-023-02881-6
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