Novel mouse line with D277N mutation in the Plau gene displays autism spectrum disorder-like traits

IntroductionGenetic technologies provide an opportunity to study the molecular basis of a wide range of hereditary pathologies, including mental disorders. Reproducing of potentially pathogenic genomic variants in cellular and animal models allows establishing their functional significance and possi...

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Main Authors:	Maxim Karagyaur, Olga Averina, Kirill Bozov, Stalik Dzhauari, Anastasia Priymak, Raushana Khaybullina, Oleg Permyakov, Vladimir Popov, Olga Grigorieva, Maria Illarionova, Liliia Shkarina, Mikhail Gulyaev, Dmitry Lebedev, Alexandra Primak, Petr Sergiev, Ekaterina Semina, Polina Klimovich, Larisa Samokhodskaya, Pavel Malkov, Yury Pirogov, Boris Tsygankov, Yuliya Chaika, Vsevolod Tkachuk, Elena Neyfeld
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-05-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	autism spectrum disorder (ASD) cognitive and behavioral tests CRISPR/Cas9 elevated plus maze PLAU gene rs1243306395
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2026.1762737/full
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