The MANGO study: a prospective investigation of oxygen enhanced and blood-oxygen level dependent MRI as imaging biomarkers of hypoxia in glioblastoma

BackgroundGlioblastoma (GBM) is the most aggressive type of brain cancer, with a 5-year survival rate of ~5% and most tumours recurring locally within months of first-line treatment. Hypoxia is associated with worse clinical outcomes in GBM, as it leads to localized resistance to radiotherapy and su...

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Hlavní autoři:	Caterina Brighi, David E. J. Waddington, Paul J. Keall, Jeremy Booth, Kieran O’Brien, Shona Silvester, Jonathon Parkinson, Marco Mueller, Jackie Yim, Dale L. Bailey, Michael Back, James Drummond
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-12-01
Edice:	Frontiers in Oncology
Témata:	glioblastoma hypoxia imaging magnetic resonance imaging radiotherapy dose painting treatment response assessment
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fonc.2023.1306164/full
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