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Targeted blockade of extracellular vesicles-mediated profibrotic vicious circle using EVs-based dual-drug delivery system to prevent liver fibrosis

Abstract Liver fibrosis, caused by various chronic liver injuries, is one of the major causes of morbidity and mortality worldwide, but there is no efficient treatments in clinic until now. Cell-cell interactions in the injured liver microenvironment play critical roles in hepatic stellate cells (HS...

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Principais autores: Jie Sun, Yi Shen, Xiaoze Wang, Ruoting Men, Xian Xing, Linling Lv, Fan Yang, Mengyi Shen, Yanyi Zheng, Xiaoli Fan, Jingping Liu, Li Yang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Journal of Nanobiotechnology
Fag:
Liver fibrosis
Hepatocyte
Extracellular vesicle
Macrophage
Hepatic stellate cell
Targeted drug delivery
Online adgang:https://doi.org/10.1186/s12951-025-03940-8
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