Depletion of regulatory T cells leads to an exacerbation of delayed-type hypersensitivity arthritis in C57BL/6 mice that can be counteracted by IL-17 blockade

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchro...

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Detalhes bibliográficos

Principais autores:	Sara Marie Atkinson, Ute Hoffmann, Alf Hamann, Emil Bach, Niels Banhos Danneskiold-Samsøe, Karsten Kristiansen, Kyle Serikawa, Brian Fox, Kim Kruse, Claus Haase, Søren Skov, Anneline Nansen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	The Company of Biologists 2016-04-01
Colecção:	Disease Models & Mechanisms
Assuntos:	Rheumatoid arthritis Regulatory T cells IL-17 Neutrophils C57BL/6 ACPA Microbiota
Acesso em linha:	http://dmm.biologists.org/content/9/4/427
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