Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson's disease

Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is crucial fo...

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Detalhes bibliográficos

Principais autores:	Ulrika Nordström, Geneviève Beauvais, Anamitra Ghosh, Baby Chakrapani Pulikkaparambil Sasidharan, Martin Lundblad, Julia Fuchs, Rajiv L. Joshi, Jack W. Lipton, Andrew Roholt, Satish Medicetty, Timothy N. Feinstein, Jennifer A. Steiner, Martha L. Escobar Galvis, Alain Prochiantz, Patrik Brundin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-01-01
coleção:	Neurobiology of Disease
Assuntos:	Retrograde degeneration TH–GFP En1+/− mice CLARITY In vivo electrochemistry Impaired dopamine release
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0969996114002848
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