2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity.

2-deoxyglucose is a glucose analog that impacts many aspects of cellular physiology. After its uptake and its phosphorylation into 2-deoxyglucose-6-phosphate (2DG6P), it interferes with several metabolic pathways including glycolysis and protein N-glycosylation. Despite this systemic effect, resista...

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Autores principales:	Clotilde Laussel, Véronique Albanèse, Francisco Javier García-Rodríguez, Alberto Ballin, Quentin Defenouillère, Sébastien Léon
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2022-08-01
Colección:	PLoS Genetics
Acceso en línea:	https://doi.org/10.1371/journal.pgen.1010169
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