Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase

Diabetic dyslipidemia requires simultaneous treatment with hypoglycemic agents and lipid-modulating drugs. We recently described glycogen phosphorylase inhibitors that reduce glycogenolysis in cells and lower plasma glucose in ob/ob mice (J. Med. Chem., 41: 2934, 1998). In evaluating the series prot...

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Principais autores:	H. James Harwood, Jr., Stephen F. Petras, Dennis J. Hoover, Dayna C. Mankowski, Victor F. Soliman, Eliot D. Sugarman, Bernard Hulin, Younggil Kwon, E. Michael Gibbs, James T. Mayne, Judith L. Treadway
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2005-03-01
coleção:	Journal of Lipid Research
Assuntos:	cholesterol synthesis glycogenolysis glycogen phosphorylase lanosterol 14α-demethylase CYP51 enzyme inhibition
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520340396
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