Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity

The long circulating half-life and inherently bivalent architecture of IgGs provide an ideal vehicle for presenting otherwise short-lived G-protein-coupled receptor agonists in a format that enables avidity-driven enhancement of potency. Here, we describe the site-specific conjugation of a dual agon...

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Autors principals:	Raul C. Camacho, Seohee You, Katharine E. D’Aquino, Wenyu Li, Yuanping Wang, Joseph Gunnet, James Littrell, Jian Shen Qi, Lijuan Kang, Wenying Jian, Mary MacDonald, Timothy Tat, Derek Steiner, Yue-Mei Zhang, James Lanter, Raymond Patch, Rui Zhang, Jiali Li, Suzanne Edavettal, Wilson Edwards, Thai Dinh, Li Ying Wang, Judy Connor, Michael Hunter, Ellen Chi, Ronald V. Swanson, James N. Leonard, Martin A. Case
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis Group 2020-01-01
Col·lecció:	mAbs
Matèries:	Antibody-peptide conjugates GPCR agonists oxyntomodulin half-life extension
Accés en línia:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1794687
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